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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCND2CCND2 isoform 1; Belongs to the cyclin family. (289 aa)    
Predicted Functional Partners:
CDKN1B
Cyclin-dependent kinase inhibitor 1B (P27, Kip1).
   
 0.999
CDK6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.999
CDK4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.999
CDKN1A
Cyclin-dependent kinase inhibitor 1A (P21, Cip1).
   
 0.999
RBL2
RB transcriptional corepressor like 2.
    
 0.990
RB1
RB transcriptional corepressor 1.
    
 0.987
CDKN2C
Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4).
    
 0.972
RBL1
RB transcriptional corepressor like 1.
    
 0.971
CDKN2B
Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).
    
 0.970
CDKN2D
Cyclin dependent kinase inhibitor 2D.
    
 0.960
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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