KLRK1 protein (Pan troglodytes) - STRING interaction network

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KLRK1

NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (216 aa)

Predicted Functional Partners:

HCST

0.999

ULBP3

0.999

MICB

0.999

RAET1E

0.998

ULBP1

0.998

RAET1G

0.995

LOC463066

0.994

RAET1L

0.992

TYROBP

0.959

KLRB1

0.947

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCST	KLRB1	ENSPTRP00000018631	ENSPTRP00000007958	Hematopoietic cell signal transducer.	Killer cell lectin like receptor B1.	0.453
HCST	KLRK1	ENSPTRP00000018631	ENSPTRP00000007992	Hematopoietic cell signal transducer.	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	0.999
HCST	LOC463066	ENSPTRP00000018631	ENSPTRP00000040901	Hematopoietic cell signal transducer.	ULBP2 isoform 1.	0.592
HCST	MICB	ENSPTRP00000018631	ENSPTRP00000050400	Hematopoietic cell signal transducer.	MHC class I polypeptide-related sequence B.	0.623
HCST	RAET1E	ENSPTRP00000018631	ENSPTRP00000039447	Hematopoietic cell signal transducer.	RAET1E isoform 5.	0.727
HCST	RAET1G	ENSPTRP00000018631	ENSPTRP00000049541	Hematopoietic cell signal transducer.	Retinoic acid early transcript 1G.	0.501
HCST	RAET1L	ENSPTRP00000018631	ENSPTRP00000041687	Hematopoietic cell signal transducer.	Retinoic acid early transcript 1.	0.592
HCST	TYROBP	ENSPTRP00000018631	ENSPTRP00000018632	Hematopoietic cell signal transducer.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.962
HCST	ULBP1	ENSPTRP00000018631	ENSPTRP00000083167	Hematopoietic cell signal transducer.	ULBP1 isoform 1.	0.744
HCST	ULBP3	ENSPTRP00000018631	ENSPTRP00000049539	Hematopoietic cell signal transducer.	UL16 binding protein 3.	0.741
KLRB1	HCST	ENSPTRP00000007958	ENSPTRP00000018631	Killer cell lectin like receptor B1.	Hematopoietic cell signal transducer.	0.453
KLRB1	KLRK1	ENSPTRP00000007958	ENSPTRP00000007992	Killer cell lectin like receptor B1.	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	0.947
KLRB1	TYROBP	ENSPTRP00000007958	ENSPTRP00000018632	Killer cell lectin like receptor B1.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.605
KLRK1	HCST	ENSPTRP00000007992	ENSPTRP00000018631	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	Hematopoietic cell signal transducer.	0.999
KLRK1	KLRB1	ENSPTRP00000007992	ENSPTRP00000007958	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	Killer cell lectin like receptor B1.	0.947
KLRK1	LOC463066	ENSPTRP00000007992	ENSPTRP00000040901	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	ULBP2 isoform 1.	0.994
KLRK1	MICB	ENSPTRP00000007992	ENSPTRP00000050400	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	MHC class I polypeptide-related sequence B.	0.999
KLRK1	RAET1E	ENSPTRP00000007992	ENSPTRP00000039447	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	RAET1E isoform 5.	0.998
KLRK1	RAET1G	ENSPTRP00000007992	ENSPTRP00000049541	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	Retinoic acid early transcript 1G.	0.995
KLRK1	RAET1L	ENSPTRP00000007992	ENSPTRP00000041687	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	Retinoic acid early transcript 1.	0.992

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