STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPRC5DG protein-coupled receptor class C group 5 member D. (345 aa)    
Predicted Functional Partners:
PSMD1
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
     
 0.652
FBXL19
F-box and leucine rich repeat protein 19.
      
 0.643
ERAP2
Aminopeptidase.
      
 0.567
EMX2
Empty spiracles homeobox 2.
      
 0.548
HSPA9
Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family.
    
 
 0.480
GPR156
G protein-coupled receptor 156.
     
 0.423
GTF2F2
General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.
    
 
 0.421
SLC25A3
Solute carrier family 25 member 3; Belongs to the mitochondrial carrier (TC 2.A.29) family.
    
 
 0.420
NOLC1
Nucleolar and coiled-body phosphoprotein 1.
    
 
 0.418
VSIG8
V-set and immunoglobulin domain-containing protein 8.
     
 0.403
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.