| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GOT1 | GOT1L1 | ENSPTRP00000004968 | ENSPTRP00000093290 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | GOT1L1 isoform 1. | 0.922 |
| GOT1 | GOT2 | ENSPTRP00000004968 | ENSPTRP00000013976 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | Aspartate aminotransferase. | 0.981 |
| GOT1 | LDHB | ENSPTRP00000004968 | ENSPTRP00000008129 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | L-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. | 0.954 |
| GOT1 | ME1 | ENSPTRP00000004968 | ENSPTRP00000031411 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | Malic enzyme. | 0.465 |
| GOT1 | ME3 | ENSPTRP00000004968 | ENSPTRP00000007130 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | Malic enzyme. | 0.465 |
| GOT1 | PC | ENSPTRP00000004968 | ENSPTRP00000045149 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.897 |
| GOT1 | PDHA1 | ENSPTRP00000004968 | ENSPTRP00000088760 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | 0.431 |
| GOT1 | PDHB | ENSPTRP00000004968 | ENSPTRP00000026010 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.565 |
| GOT1L1 | GOT1 | ENSPTRP00000093290 | ENSPTRP00000004968 | GOT1L1 isoform 1. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.922 |
| GOT1L1 | GOT2 | ENSPTRP00000093290 | ENSPTRP00000013976 | GOT1L1 isoform 1. | Aspartate aminotransferase. | 0.969 |
| GOT1L1 | LDHB | ENSPTRP00000093290 | ENSPTRP00000008129 | GOT1L1 isoform 1. | L-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. | 0.943 |
| GOT1L1 | ME1 | ENSPTRP00000093290 | ENSPTRP00000031411 | GOT1L1 isoform 1. | Malic enzyme. | 0.412 |
| GOT1L1 | ME3 | ENSPTRP00000093290 | ENSPTRP00000007130 | GOT1L1 isoform 1. | Malic enzyme. | 0.412 |
| GOT1L1 | PC | ENSPTRP00000093290 | ENSPTRP00000045149 | GOT1L1 isoform 1. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.879 |
| GOT2 | GOT1 | ENSPTRP00000013976 | ENSPTRP00000004968 | Aspartate aminotransferase. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.981 |
| GOT2 | GOT1L1 | ENSPTRP00000013976 | ENSPTRP00000093290 | Aspartate aminotransferase. | GOT1L1 isoform 1. | 0.969 |
| GOT2 | LDHB | ENSPTRP00000013976 | ENSPTRP00000008129 | Aspartate aminotransferase. | L-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. | 0.958 |
| GOT2 | ME1 | ENSPTRP00000013976 | ENSPTRP00000031411 | Aspartate aminotransferase. | Malic enzyme. | 0.461 |
| GOT2 | ME3 | ENSPTRP00000013976 | ENSPTRP00000007130 | Aspartate aminotransferase. | Malic enzyme. | 0.461 |
| GOT2 | PC | ENSPTRP00000013976 | ENSPTRP00000045149 | Aspartate aminotransferase. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.913 |
