STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCNT1Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of SIV infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing [...] (725 aa)    
Predicted Functional Partners:
CDK9
Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily.
   
 0.999
AFF4
AF4/FMR2 family, member 4.
   
 0.993
HEXIM1
Hexamethylene bis-acetamide inducible 1.
   
 
 0.993
AFF4-2
AF4/FMR2 family member 4.
   
 0.993
BRD4
Bromodomain containing 4.
   
 
 0.988
AFF1
AF4/FMR2 family, member 1.
   
 0.983
CCNT2
CCNT2 isoform 4; Belongs to the cyclin family.
    
0.975
LARP7
La ribonucleoprotein domain family member 7.
   
 0.969
MLLT1
Myeloid/lymphoid or mixed-lineage leukemia translocated to, 1.
   
 0.963
ELL
Elongation factor for RNA polymerase II.
    
 0.959
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.