STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)    
Predicted Functional Partners:
LRP6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 0.984
FZD1
FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.982
FZD7
Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.981
FZD10
Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.980
PORCN
Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family.
    
 0.979
FZD6
Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.978
FZD2
FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.977
LRP5
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 0.977
FZD9
Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.973
FZD4
FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.972
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.