| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BUB1 | ESPL1 | ENSPTRP00000074938 | ENSPTRP00000008526 | BUB1 isoform 1. | Extra spindle pole bodies like 1, separase. | 0.978 |
| BUB1 | PTTG1 | ENSPTRP00000074938 | ENSPTRP00000029883 | BUB1 isoform 1. | Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] | 0.815 |
| BUB1 | PTTG2 | ENSPTRP00000074938 | ENSPTRP00000092610 | BUB1 isoform 1. | PTTG2 isoform 1. | 0.823 |
| BUB1 | PTTG3 | ENSPTRP00000074938 | ENSPTRP00000088706 | BUB1 isoform 1. | Putative pituitary tumor-transforming gene 3 protein; Belongs to the securin family. | 0.826 |
| BUB1 | RAD21 | ENSPTRP00000074938 | ENSPTRP00000035102 | BUB1 isoform 1. | RAD21 cohesin complex component. | 0.529 |
| BUB1 | REC8 | ENSPTRP00000074938 | ENSPTRP00000090423 | BUB1 isoform 1. | Meiotic recombination protein REC8-like 1. | 0.479 |
| BUB1 | SMC1A | ENSPTRP00000074938 | ENSPTRP00000037651 | BUB1 isoform 1. | Structural maintenance of chromosomes protein. | 0.510 |
| BUB1 | SMC1B | ENSPTRP00000074938 | ENSPTRP00000042717 | BUB1 isoform 1. | Structural maintenance of chromosomes protein. | 0.481 |
| BUB1 | SMC3 | ENSPTRP00000074938 | ENSPTRP00000042743 | BUB1 isoform 1. | Structural maintenance of chromosomes protein. | 0.523 |
| ESPL1 | BUB1 | ENSPTRP00000008526 | ENSPTRP00000074938 | Extra spindle pole bodies like 1, separase. | BUB1 isoform 1. | 0.978 |
| ESPL1 | PTTG1 | ENSPTRP00000008526 | ENSPTRP00000029883 | Extra spindle pole bodies like 1, separase. | Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] | 0.998 |
| ESPL1 | PTTG2 | ENSPTRP00000008526 | ENSPTRP00000092610 | Extra spindle pole bodies like 1, separase. | PTTG2 isoform 1. | 0.998 |
| ESPL1 | PTTG3 | ENSPTRP00000008526 | ENSPTRP00000088706 | Extra spindle pole bodies like 1, separase. | Putative pituitary tumor-transforming gene 3 protein; Belongs to the securin family. | 0.980 |
| ESPL1 | RAD21 | ENSPTRP00000008526 | ENSPTRP00000035102 | Extra spindle pole bodies like 1, separase. | RAD21 cohesin complex component. | 0.997 |
| ESPL1 | REC8 | ENSPTRP00000008526 | ENSPTRP00000090423 | Extra spindle pole bodies like 1, separase. | Meiotic recombination protein REC8-like 1. | 0.987 |
| ESPL1 | SMC1A | ENSPTRP00000008526 | ENSPTRP00000037651 | Extra spindle pole bodies like 1, separase. | Structural maintenance of chromosomes protein. | 0.985 |
| ESPL1 | SMC1B | ENSPTRP00000008526 | ENSPTRP00000042717 | Extra spindle pole bodies like 1, separase. | Structural maintenance of chromosomes protein. | 0.982 |
| ESPL1 | SMC3 | ENSPTRP00000008526 | ENSPTRP00000042743 | Extra spindle pole bodies like 1, separase. | Structural maintenance of chromosomes protein. | 0.988 |
| ESPL1 | STAG1 | ENSPTRP00000008526 | ENSPTRP00000086284 | Extra spindle pole bodies like 1, separase. | Stromal antigen 1. | 0.974 |
| PTTG1 | BUB1 | ENSPTRP00000029883 | ENSPTRP00000074938 | Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] | BUB1 isoform 1. | 0.815 |
