ESPL1 protein (Pan troglodytes) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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[Homology]

Score

ESPL1

Extra spindle pole bodies like 1, separase. (2118 aa)

Predicted Functional Partners:

CCNB1

0.999

PTTG1

0.999

PTTG2

0.999

PTTG3

0.997

RAD21

0.992

SMC3

0.986

REC8

0.986

STAG1

0.979

STAG2

0.978

SMC1A

0.977

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNB1	ESPL1	ENSPTRP00000029014	ENSPTRP00000008526	CCNB1 isoform 1; Belongs to the cyclin family.	Extra spindle pole bodies like 1, separase.	0.999
CCNB1	PTTG1	ENSPTRP00000029014	ENSPTRP00000029883	CCNB1 isoform 1; Belongs to the cyclin family.	Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...]	0.907
CCNB1	PTTG2	ENSPTRP00000029014	ENSPTRP00000092610	CCNB1 isoform 1; Belongs to the cyclin family.	PTTG2 isoform 1.	0.876
CCNB1	PTTG3	ENSPTRP00000029014	ENSPTRP00000088706	CCNB1 isoform 1; Belongs to the cyclin family.	Putative pituitary tumor-transforming gene 3 protein; Belongs to the securin family.	0.867
CCNB1	RAD21	ENSPTRP00000029014	ENSPTRP00000035102	CCNB1 isoform 1; Belongs to the cyclin family.	RAD21 cohesin complex component.	0.602
CCNB1	REC8	ENSPTRP00000029014	ENSPTRP00000090423	CCNB1 isoform 1; Belongs to the cyclin family.	Meiotic recombination protein REC8-like 1.	0.408
CCNB1	SMC1A	ENSPTRP00000029014	ENSPTRP00000037651	CCNB1 isoform 1; Belongs to the cyclin family.	Structural maintenance of chromosomes protein.	0.410
CCNB1	SMC3	ENSPTRP00000029014	ENSPTRP00000042743	CCNB1 isoform 1; Belongs to the cyclin family.	Structural maintenance of chromosomes protein.	0.476
ESPL1	CCNB1	ENSPTRP00000008526	ENSPTRP00000029014	Extra spindle pole bodies like 1, separase.	CCNB1 isoform 1; Belongs to the cyclin family.	0.999
ESPL1	PTTG1	ENSPTRP00000008526	ENSPTRP00000029883	Extra spindle pole bodies like 1, separase.	Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...]	0.999
ESPL1	PTTG2	ENSPTRP00000008526	ENSPTRP00000092610	Extra spindle pole bodies like 1, separase.	PTTG2 isoform 1.	0.999
ESPL1	PTTG3	ENSPTRP00000008526	ENSPTRP00000088706	Extra spindle pole bodies like 1, separase.	Putative pituitary tumor-transforming gene 3 protein; Belongs to the securin family.	0.997
ESPL1	RAD21	ENSPTRP00000008526	ENSPTRP00000035102	Extra spindle pole bodies like 1, separase.	RAD21 cohesin complex component.	0.992
ESPL1	REC8	ENSPTRP00000008526	ENSPTRP00000090423	Extra spindle pole bodies like 1, separase.	Meiotic recombination protein REC8-like 1.	0.986
ESPL1	SMC1A	ENSPTRP00000008526	ENSPTRP00000037651	Extra spindle pole bodies like 1, separase.	Structural maintenance of chromosomes protein.	0.977
ESPL1	SMC3	ENSPTRP00000008526	ENSPTRP00000042743	Extra spindle pole bodies like 1, separase.	Structural maintenance of chromosomes protein.	0.986
ESPL1	STAG1	ENSPTRP00000008526	ENSPTRP00000086284	Extra spindle pole bodies like 1, separase.	Stromal antigen 1.	0.979
ESPL1	STAG2	ENSPTRP00000008526	ENSPTRP00000038307	Extra spindle pole bodies like 1, separase.	Stromal antigen 2.	0.978
PTTG1	CCNB1	ENSPTRP00000029883	ENSPTRP00000029014	Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...]	CCNB1 isoform 1; Belongs to the cyclin family.	0.907
PTTG1	ESPL1	ENSPTRP00000029883	ENSPTRP00000008526	Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...]	Extra spindle pole bodies like 1, separase.	0.999