STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NAB2NGFI-A binding protein 2 (EGR1 binding protein 2). (525 aa)    
Predicted Functional Partners:
EGR2
Early growth response 2.
   
 0.967
CHD4
Chromodomain helicase DNA binding protein 4.
   
 0.939
EGR1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
   
 0.933
EGR3
Early growth response 3.
   
 0.835
CHD3
Chromodomain helicase DNA binding protein 3.
   
 0.798
EGR4
Early growth response 4.
   
 0.744
STAT6
Signal transducer and activator of transcription.
      
 0.695
ZC3H14
ZC3H14 isoform 5.
      
 0.663
CDK5R1
Cyclin-dependent kinase 5 activator.
   
 
  0.648
NXF1
Nuclear RNA export factor 1.
      
 0.621
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.