IRAK3 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPTRP00000065244	IL1R1	ENSPTRP00000065244	ENSPTRP00000075043	annotation not available	Interleukin 1 receptor, type I.	0.908
ENSPTRP00000065244	IRAK1	ENSPTRP00000065244	ENSPTRP00000068595	annotation not available	Interleukin 1 receptor associated kinase 1.	0.918
ENSPTRP00000065244	IRAK1-2	ENSPTRP00000065244	ENSPTRP00000038647	annotation not available	Interleukin-1 receptor-associated kinase 1.	0.918
ENSPTRP00000065244	IRAK2	ENSPTRP00000065244	ENSPTRP00000025212	annotation not available	Interleukin-1 receptor-associated kinase 2.	0.977
ENSPTRP00000065244	IRAK3	ENSPTRP00000065244	ENSPTRP00000008814	annotation not available	Interleukin-1 receptor-associated kinase 3.	0.846
ENSPTRP00000065244	IRAK4	ENSPTRP00000065244	ENSPTRP00000008285	annotation not available	Interleukin-1 receptor-associated kinase 4.	0.938
ENSPTRP00000065244	MYD88	ENSPTRP00000065244	ENSPTRP00000061524	annotation not available	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.960
ENSPTRP00000065244	NGFR	ENSPTRP00000065244	ENSPTRP00000015928	annotation not available	Nerve growth factor receptor.	0.942
IL1R1	ENSPTRP00000065244	ENSPTRP00000075043	ENSPTRP00000065244	Interleukin 1 receptor, type I.	annotation not available	0.908
IL1R1	IRAK1	ENSPTRP00000075043	ENSPTRP00000068595	Interleukin 1 receptor, type I.	Interleukin 1 receptor associated kinase 1.	0.932
IL1R1	IRAK1-2	ENSPTRP00000075043	ENSPTRP00000038647	Interleukin 1 receptor, type I.	Interleukin-1 receptor-associated kinase 1.	0.992
IL1R1	IRAK2	ENSPTRP00000075043	ENSPTRP00000025212	Interleukin 1 receptor, type I.	Interleukin-1 receptor-associated kinase 2.	0.881
IL1R1	IRAK3	ENSPTRP00000075043	ENSPTRP00000008814	Interleukin 1 receptor, type I.	Interleukin-1 receptor-associated kinase 3.	0.695
IL1R1	IRAK4	ENSPTRP00000075043	ENSPTRP00000008285	Interleukin 1 receptor, type I.	Interleukin-1 receptor-associated kinase 4.	0.991
IL1R1	MYD88	ENSPTRP00000075043	ENSPTRP00000061524	Interleukin 1 receptor, type I.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.998
IL1R1	TLR2	ENSPTRP00000075043	ENSPTRP00000028379	Interleukin 1 receptor, type I.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.594
IL1R1	TRAF6	ENSPTRP00000075043	ENSPTRP00000006096	Interleukin 1 receptor, type I.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.995
IRAK1	ENSPTRP00000065244	ENSPTRP00000068595	ENSPTRP00000065244	Interleukin 1 receptor associated kinase 1.	annotation not available	0.918
IRAK1	IL1R1	ENSPTRP00000068595	ENSPTRP00000075043	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor, type I.	0.932
IRAK1	IRAK2	ENSPTRP00000068595	ENSPTRP00000025212	Interleukin 1 receptor associated kinase 1.	Interleukin-1 receptor-associated kinase 2.	0.869