STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)    
Predicted Functional Partners:
PIDD1
Leucine-rich repeats and death domain containing.
    
 0.999
CASP2
Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
 0.947
CASP2-2
Caspase 2.
    
 0.947
TRADD
TNFRSF1A-associated via death domain.
      
 0.794
FADD
FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
    
 
 0.789
CYFIP2
Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.
      
 0.698
NSUN3
NOP2/Sun domain family, member 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
      
 0.666
RNF213
RNF213 isoform 1.
    
 0.646
RIPK1
Receptor (TNFRSF)-interacting serine-threonine kinase 1.
    
 
 0.600
CASP9
CASP9 isoform 4; Belongs to the peptidase C14A family.
    
 0.578
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (58%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.