STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BRAPBRCA1-associated protein. (592 aa)    
Predicted Functional Partners:
KSR2
Kinase suppressor of ras 2.
    
 0.956
NRAS
Neuroblastoma RAS viral (V-ras) oncogene homolog.
    
  0.941
HRAS
V-Ha-ras Harvey rat sarcoma viral oncogene homolog.
    
  0.941
KRAS
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.
    
  0.941
RRAS2
Related RAS viral (R-ras) oncogene homolog 2.
    
  0.931
RRAS
Related RAS viral (R-ras) oncogene homolog.
    
  0.931
MRAS
Muscle RAS oncogene homolog.
    
  0.931
BRCA1
Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]
    
 
 0.897
KSR1
KSR1 isoform 4.
    
 0.815
WDR20
WD repeat domain 20.
   
  
 0.804
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.