KSR2 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAP	KSR1	ENSPTRP00000009271	ENSPTRP00000065667	BRCA1-associated protein.	KSR1 isoform 4.	0.989
BRAP	KSR2	ENSPTRP00000009271	ENSPTRP00000009350	BRCA1-associated protein.	Kinase suppressor of ras 2.	0.980
CNKSR1	CNKSR2	ENSPTRP00000081491	ENSPTRP00000078553	CNKSR1 isoform 5.	Connector enhancer of kinase suppressor of Ras 2.	0.453
CNKSR1	ENSPTRP00000065064	ENSPTRP00000081491	ENSPTRP00000065064	CNKSR1 isoform 5.	annotation not available	0.509
CNKSR1	ENSPTRP00000069037	ENSPTRP00000081491	ENSPTRP00000069037	CNKSR1 isoform 5.	annotation not available	0.509
CNKSR1	ENSPTRP00000074910	ENSPTRP00000081491	ENSPTRP00000074910	CNKSR1 isoform 5.	annotation not available	0.509
CNKSR1	KSR1	ENSPTRP00000081491	ENSPTRP00000065667	CNKSR1 isoform 5.	KSR1 isoform 4.	0.822
CNKSR1	KSR2	ENSPTRP00000081491	ENSPTRP00000009350	CNKSR1 isoform 5.	Kinase suppressor of ras 2.	0.728
CNKSR1	MAP2K1	ENSPTRP00000081491	ENSPTRP00000063228	CNKSR1 isoform 5.	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	0.509
CNKSR1	MAP2K2	ENSPTRP00000081491	ENSPTRP00000017496	CNKSR1 isoform 5.	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.509
CNKSR2	CNKSR1	ENSPTRP00000078553	ENSPTRP00000081491	Connector enhancer of kinase suppressor of Ras 2.	CNKSR1 isoform 5.	0.453
CNKSR2	ENSPTRP00000065064	ENSPTRP00000078553	ENSPTRP00000065064	Connector enhancer of kinase suppressor of Ras 2.	annotation not available	0.555
CNKSR2	ENSPTRP00000069037	ENSPTRP00000078553	ENSPTRP00000069037	Connector enhancer of kinase suppressor of Ras 2.	annotation not available	0.555
CNKSR2	ENSPTRP00000074910	ENSPTRP00000078553	ENSPTRP00000074910	Connector enhancer of kinase suppressor of Ras 2.	annotation not available	0.555
CNKSR2	KSR1	ENSPTRP00000078553	ENSPTRP00000065667	Connector enhancer of kinase suppressor of Ras 2.	KSR1 isoform 4.	0.840
CNKSR2	KSR2	ENSPTRP00000078553	ENSPTRP00000009350	Connector enhancer of kinase suppressor of Ras 2.	Kinase suppressor of ras 2.	0.754
CNKSR2	MAP2K1	ENSPTRP00000078553	ENSPTRP00000063228	Connector enhancer of kinase suppressor of Ras 2.	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	0.555
CNKSR2	MAP2K2	ENSPTRP00000078553	ENSPTRP00000017496	Connector enhancer of kinase suppressor of Ras 2.	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.555
ENSPTRP00000065064	CNKSR1	ENSPTRP00000065064	ENSPTRP00000081491	annotation not available	CNKSR1 isoform 5.	0.509
ENSPTRP00000065064	CNKSR2	ENSPTRP00000065064	ENSPTRP00000078553	annotation not available	Connector enhancer of kinase suppressor of Ras 2.	0.555