HPD protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAH	GOT2	ENSPTRP00000091044	ENSPTRP00000013976	Fumarylacetoacetase.	Aspartate aminotransferase.	0.507
FAH	HGD	ENSPTRP00000091044	ENSPTRP00000026325	Fumarylacetoacetase.	Homogentisate 1,2-dioxygenase.	0.884
FAH	HPD	ENSPTRP00000091044	ENSPTRP00000009453	Fumarylacetoacetase.	4-hydroxyphenylpyruvate dioxygenase.	0.936
FAH	TAT	ENSPTRP00000091044	ENSPTRP00000014220	Fumarylacetoacetase.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.643
GOT1	GOT1L1	ENSPTRP00000004968	ENSPTRP00000093290	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	GOT1L1 isoform 1.	0.922
GOT1	GOT2	ENSPTRP00000004968	ENSPTRP00000013976	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	Aspartate aminotransferase.	0.981
GOT1	HPD	ENSPTRP00000004968	ENSPTRP00000009453	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	4-hydroxyphenylpyruvate dioxygenase.	0.958
GOT1	IL4I1	ENSPTRP00000004968	ENSPTRP00000055736	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	Amine oxidase.	0.905
GOT1	MIF	ENSPTRP00000004968	ENSPTRP00000090708	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	Macrophage migration inhibitory factor.	0.920
GOT1	TAT	ENSPTRP00000004968	ENSPTRP00000014220	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.959
GOT1L1	GOT1	ENSPTRP00000093290	ENSPTRP00000004968	GOT1L1 isoform 1.	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	0.922
GOT1L1	GOT2	ENSPTRP00000093290	ENSPTRP00000013976	GOT1L1 isoform 1.	Aspartate aminotransferase.	0.969
GOT1L1	HPD	ENSPTRP00000093290	ENSPTRP00000009453	GOT1L1 isoform 1.	4-hydroxyphenylpyruvate dioxygenase.	0.953
GOT1L1	IL4I1	ENSPTRP00000093290	ENSPTRP00000055736	GOT1L1 isoform 1.	Amine oxidase.	0.900
GOT1L1	MIF	ENSPTRP00000093290	ENSPTRP00000090708	GOT1L1 isoform 1.	Macrophage migration inhibitory factor.	0.907
GOT1L1	TAT	ENSPTRP00000093290	ENSPTRP00000014220	GOT1L1 isoform 1.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.947
GOT2	FAH	ENSPTRP00000013976	ENSPTRP00000091044	Aspartate aminotransferase.	Fumarylacetoacetase.	0.507
GOT2	GOT1	ENSPTRP00000013976	ENSPTRP00000004968	Aspartate aminotransferase.	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	0.981
GOT2	GOT1L1	ENSPTRP00000013976	ENSPTRP00000093290	Aspartate aminotransferase.	GOT1L1 isoform 1.	0.969
GOT2	HPD	ENSPTRP00000013976	ENSPTRP00000009453	Aspartate aminotransferase.	4-hydroxyphenylpyruvate dioxygenase.	0.954