SACS protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SACS

SACS isoform 1. (4579 aa)

Predicted Functional Partners:

INCENP

0.717

DIABLO

0.672

APAF1

0.646

CDCA8

0.612

ATP5F1B

0.612

TRADD

0.563

AURKB

0.548

AURKC

0.548

AURKA

0.548

AURKB-2

0.548

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	AURKA	ENSPTRP00000042795	ENSPTRP00000023475	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily.	0.577
APAF1	AURKB	ENSPTRP00000042795	ENSPTRP00000014877	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	AURKB isoform 1; Belongs to the protein kinase superfamily.	0.577
APAF1	AURKB-2	ENSPTRP00000042795	ENSPTRP00000073237	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Aurora kinase B.	0.577
APAF1	AURKC	ENSPTRP00000042795	ENSPTRP00000019871	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	AURKC isoform 1; Belongs to the protein kinase superfamily.	0.577
APAF1	DIABLO	ENSPTRP00000042795	ENSPTRP00000071257	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Diablo, IAP-binding mitochondrial protein.	0.904
APAF1	SACS	ENSPTRP00000042795	ENSPTRP00000009720	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	SACS isoform 1.	0.646
APAF1	TRADD	ENSPTRP00000042795	ENSPTRP00000046129	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	TNFRSF1A-associated via death domain.	0.480
ATP5F1B	AURKA	ENSPTRP00000008686	ENSPTRP00000023475	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily.	0.700
ATP5F1B	AURKB	ENSPTRP00000008686	ENSPTRP00000014877	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	AURKB isoform 1; Belongs to the protein kinase superfamily.	0.700
ATP5F1B	AURKB-2	ENSPTRP00000008686	ENSPTRP00000073237	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Aurora kinase B.	0.700
ATP5F1B	AURKC	ENSPTRP00000008686	ENSPTRP00000019871	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	AURKC isoform 1; Belongs to the protein kinase superfamily.	0.700
ATP5F1B	INCENP	ENSPTRP00000008686	ENSPTRP00000061804	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Inner centromere protein antigens 135/155kDa.	0.935
ATP5F1B	SACS	ENSPTRP00000008686	ENSPTRP00000009720	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	SACS isoform 1.	0.612
AURKA	APAF1	ENSPTRP00000023475	ENSPTRP00000042795	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.577
AURKA	ATP5F1B	ENSPTRP00000023475	ENSPTRP00000008686	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.700
AURKA	AURKB	ENSPTRP00000023475	ENSPTRP00000014877	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily.	AURKB isoform 1; Belongs to the protein kinase superfamily.	0.812
AURKA	AURKB-2	ENSPTRP00000023475	ENSPTRP00000073237	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily.	Aurora kinase B.	0.812
AURKA	AURKC	ENSPTRP00000023475	ENSPTRP00000019871	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily.	AURKC isoform 1; Belongs to the protein kinase superfamily.	0.811
AURKA	CDCA8	ENSPTRP00000023475	ENSPTRP00000000973	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily.	Cell division cycle associated 8.	0.948
AURKA	INCENP	ENSPTRP00000023475	ENSPTRP00000061804	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily.	Inner centromere protein antigens 135/155kDa.	0.961