ITM2B protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	CST3	ENSPTRP00000093932	ENSPTRP00000090475	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	CST3 isoform 1; Belongs to the cystatin family.	0.651
APP	ITM2B	ENSPTRP00000093932	ENSPTRP00000009973	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Integral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers; Belongs to the ITM2 family.	0.849
APP	UBC	ENSPTRP00000093932	ENSPTRP00000050925	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.420
CAB39L	CDADC1	ENSPTRP00000009989	ENSPTRP00000009987	Calcium-binding protein 39-like.	Cytidine and dCMP deaminase domain containing 1.	0.774
CAB39L	CYSLTR2	ENSPTRP00000009989	ENSPTRP00000092409	Calcium-binding protein 39-like.	Cysteinyl leukotriene receptor 2.	0.774
CAB39L	FNDC3A	ENSPTRP00000009989	ENSPTRP00000083936	Calcium-binding protein 39-like.	Fibronectin type III domain containing 3A.	0.774
CAB39L	ITM2B	ENSPTRP00000009989	ENSPTRP00000009973	Calcium-binding protein 39-like.	Integral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers; Belongs to the ITM2 family.	0.775
CAB39L	LPAR6	ENSPTRP00000009989	ENSPTRP00000009975	Calcium-binding protein 39-like.	Lysophosphatidic acid receptor 6.	0.707
CAB39L	MLNR	ENSPTRP00000009989	ENSPTRP00000085599	Calcium-binding protein 39-like.	Motilin receptor; Belongs to the G-protein coupled receptor 1 family.	0.774
CAB39L	RCBTB2	ENSPTRP00000009989	ENSPTRP00000072566	Calcium-binding protein 39-like.	RCC1 and BTB domain containing protein 2.	0.775
CDADC1	CAB39L	ENSPTRP00000009987	ENSPTRP00000009989	Cytidine and dCMP deaminase domain containing 1.	Calcium-binding protein 39-like.	0.774
CDADC1	CYSLTR2	ENSPTRP00000009987	ENSPTRP00000092409	Cytidine and dCMP deaminase domain containing 1.	Cysteinyl leukotriene receptor 2.	0.774
CDADC1	FNDC3A	ENSPTRP00000009987	ENSPTRP00000083936	Cytidine and dCMP deaminase domain containing 1.	Fibronectin type III domain containing 3A.	0.774
CDADC1	ITM2B	ENSPTRP00000009987	ENSPTRP00000009973	Cytidine and dCMP deaminase domain containing 1.	Integral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers; Belongs to the ITM2 family.	0.774
CDADC1	LPAR6	ENSPTRP00000009987	ENSPTRP00000009975	Cytidine and dCMP deaminase domain containing 1.	Lysophosphatidic acid receptor 6.	0.707
CDADC1	MLNR	ENSPTRP00000009987	ENSPTRP00000085599	Cytidine and dCMP deaminase domain containing 1.	Motilin receptor; Belongs to the G-protein coupled receptor 1 family.	0.706
CDADC1	RCBTB2	ENSPTRP00000009987	ENSPTRP00000072566	Cytidine and dCMP deaminase domain containing 1.	RCC1 and BTB domain containing protein 2.	0.786
CST3	APP	ENSPTRP00000090475	ENSPTRP00000093932	CST3 isoform 1; Belongs to the cystatin family.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.651
CST3	ITM2B	ENSPTRP00000090475	ENSPTRP00000009973	CST3 isoform 1; Belongs to the cystatin family.	Integral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers; Belongs to the ITM2 family.	0.914
CYSLTR2	CAB39L	ENSPTRP00000092409	ENSPTRP00000009989	Cysteinyl leukotriene receptor 2.	Calcium-binding protein 39-like.	0.774