| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP3 | CASP7 | ENSPTRP00000054330 | ENSPTRP00000074501 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | CASP7 isoform 1; Belongs to the peptidase C14A family. | 0.973 |
| CASP3 | CASP9 | ENSPTRP00000054330 | ENSPTRP00000089496 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | CASP9 isoform 4; Belongs to the peptidase C14A family. | 0.998 |
| CASP3 | PARP1 | ENSPTRP00000054330 | ENSPTRP00000003457 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.997 |
| CASP3 | PARP2 | ENSPTRP00000054330 | ENSPTRP00000010339 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase. | 0.938 |
| CASP7 | CASP3 | ENSPTRP00000074501 | ENSPTRP00000054330 | CASP7 isoform 1; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.973 |
| CASP7 | CASP9 | ENSPTRP00000074501 | ENSPTRP00000089496 | CASP7 isoform 1; Belongs to the peptidase C14A family. | CASP9 isoform 4; Belongs to the peptidase C14A family. | 0.987 |
| CASP7 | PARP1 | ENSPTRP00000074501 | ENSPTRP00000003457 | CASP7 isoform 1; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.990 |
| CASP7 | PARP2 | ENSPTRP00000074501 | ENSPTRP00000010339 | CASP7 isoform 1; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase. | 0.938 |
| CASP9 | CASP3 | ENSPTRP00000089496 | ENSPTRP00000054330 | CASP9 isoform 4; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.998 |
| CASP9 | CASP7 | ENSPTRP00000089496 | ENSPTRP00000074501 | CASP9 isoform 4; Belongs to the peptidase C14A family. | CASP7 isoform 1; Belongs to the peptidase C14A family. | 0.987 |
| CASP9 | PARP1 | ENSPTRP00000089496 | ENSPTRP00000003457 | CASP9 isoform 4; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.970 |
| CASP9 | PARP2 | ENSPTRP00000089496 | ENSPTRP00000010339 | CASP9 isoform 4; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase. | 0.945 |
| LIG3 | PARP1 | ENSPTRP00000015364 | ENSPTRP00000003457 | DNA ligase. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.815 |
| LIG3 | PARP2 | ENSPTRP00000015364 | ENSPTRP00000010339 | DNA ligase. | Poly [ADP-ribose] polymerase. | 0.919 |
| LIG3 | POLB | ENSPTRP00000015364 | ENSPTRP00000034604 | DNA ligase. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.988 |
| LIG3 | RNF146 | ENSPTRP00000015364 | ENSPTRP00000031718 | DNA ligase. | Ring finger protein 146. | 0.918 |
| PARG | PARP1 | ENSPTRP00000058989 | ENSPTRP00000003457 | Uncharacterized protein. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.929 |
| PARG | PARP2 | ENSPTRP00000058989 | ENSPTRP00000010339 | Uncharacterized protein. | Poly [ADP-ribose] polymerase. | 0.919 |
| PARG | POLB | ENSPTRP00000058989 | ENSPTRP00000034604 | Uncharacterized protein. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.487 |
| PARG-2 | PARP1 | ENSPTRP00000062052 | ENSPTRP00000003457 | Poly(ADP-ribose) glycohydrolase. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.929 |
