| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BID | CASP3 | ENSPTRP00000024179 | ENSPTRP00000054330 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.832 |
| BID | CASP7 | ENSPTRP00000024179 | ENSPTRP00000074501 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | CASP7 isoform 1; Belongs to the peptidase C14A family. | 0.595 |
| BID | CASP8 | ENSPTRP00000024179 | ENSPTRP00000021879 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.994 |
| BID | GZMB | ENSPTRP00000024179 | ENSPTRP00000087293 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | GZMB isoform 2; Belongs to the peptidase S1 family. | 0.973 |
| CASP3 | BID | ENSPTRP00000054330 | ENSPTRP00000024179 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.832 |
| CASP3 | CASP7 | ENSPTRP00000054330 | ENSPTRP00000074501 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | CASP7 isoform 1; Belongs to the peptidase C14A family. | 0.973 |
| CASP3 | CASP8 | ENSPTRP00000054330 | ENSPTRP00000021879 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.994 |
| CASP3 | CD4 | ENSPTRP00000054330 | ENSPTRP00000054833 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.821 |
| CASP3 | DFFA | ENSPTRP00000054330 | ENSPTRP00000000259 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | DNA fragmentation factor subunit alpha. | 0.998 |
| CASP3 | GZMB | ENSPTRP00000054330 | ENSPTRP00000087293 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | GZMB isoform 2; Belongs to the peptidase S1 family. | 0.979 |
| CASP3 | PARP1 | ENSPTRP00000054330 | ENSPTRP00000003457 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.997 |
| CASP7 | BID | ENSPTRP00000074501 | ENSPTRP00000024179 | CASP7 isoform 1; Belongs to the peptidase C14A family. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.595 |
| CASP7 | CASP3 | ENSPTRP00000074501 | ENSPTRP00000054330 | CASP7 isoform 1; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.973 |
| CASP7 | CASP8 | ENSPTRP00000074501 | ENSPTRP00000021879 | CASP7 isoform 1; Belongs to the peptidase C14A family. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.991 |
| CASP7 | CD4 | ENSPTRP00000074501 | ENSPTRP00000054833 | CASP7 isoform 1; Belongs to the peptidase C14A family. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.488 |
| CASP7 | DFFA | ENSPTRP00000074501 | ENSPTRP00000000259 | CASP7 isoform 1; Belongs to the peptidase C14A family. | DNA fragmentation factor subunit alpha. | 0.795 |
| CASP7 | GZMB | ENSPTRP00000074501 | ENSPTRP00000087293 | CASP7 isoform 1; Belongs to the peptidase C14A family. | GZMB isoform 2; Belongs to the peptidase S1 family. | 0.923 |
| CASP7 | PARP1 | ENSPTRP00000074501 | ENSPTRP00000003457 | CASP7 isoform 1; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.990 |
| CASP8 | BID | ENSPTRP00000021879 | ENSPTRP00000024179 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.994 |
| CASP8 | CASP3 | ENSPTRP00000021879 | ENSPTRP00000054330 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.994 |
