STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSM2INSM transcriptional repressor 2. (568 aa)    
Predicted Functional Partners:
NEUROG3
NEUROG3 isoform 1.
   
 0.888
KDM1A
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
    
 
 0.878
RCOR1
REST corepressor 1.
    
 
 0.787
RIPPLY3
RIPPLY3 isoform 3.
      
 0.719
PPY
Pancreatic polypeptide.
   
  
 0.669
NEUROG1
NEUROG1 isoform 1.
   
 0.638
PTPRN
Protein tyrosine phosphatase, receptor type, N.
    
 
 0.607
SORBS1
Sorbin and SH3 domain containing 1.
    
 
 0.596
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
      
 0.582
RACK1
Receptor for activated C kinase 1.
      
 0.574
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.