STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRR1Leucine rich repeat protein 1. (414 aa)    
Predicted Functional Partners:
RBX1
Ring-box 1, E3 ubiquitin protein ligase.
   
 0.954
CUL2
CUL2 isoform 8; Belongs to the cullin family.
    
 0.931
CUL2-2
Cullin 2.
    
 0.931
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
 
 0.900
MCM3
DNA helicase; Belongs to the MCM family.
   
 
 0.878
ENSPTRP00000075898
annotation not available
    
 0.875
LOC107968511
Elongin-C-like.
    
 0.875
ELOC
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); Belongs to the SKP1 family.
    
 0.875
ELOC-2
Elongin C.
    
 0.875
WDHD1
WDHD1 isoform 1.
   
 
 0.869
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.