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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKL1Cyclin-dependent kinase-like 1 (CDC2-related kinase); Belongs to the protein kinase superfamily. (358 aa)    
Predicted Functional Partners:
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.
      
 0.776
CDKL4
CDKL4 isoform 1.
  
 
  
0.730
MCL1
Myeloid cell leukemia sequence 1 (BCL2-related).
   
  
 0.622
YWHAG
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Belongs to the 14-3-3 family.
      
 0.617
RPS6KB1
Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
  
   
0.581
DNAAF1
Dynein assembly factor 1, axonemal.
   
    0.566
CTXN1
CTXN1 isoform 1.
   
    0.566
ROS1
Proto-oncogene tyrosine-protein kinase ROS isoform X5.
   
  
0.504
EIF2AK2
Eukaryotic translation initiation factor 2-alpha kinase 2.
  
  
0.487
LRRK1
Leucine-rich repeat kinase 1.
   
  
0.477
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.