STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)    
Predicted Functional Partners:
BRAF
BRAF isoform 1; Belongs to the protein kinase superfamily.
    
0.921
ARAF
V-raf murine sarcoma 3611 viral oncogene homolog.
    
0.915
TRPV4
Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family.
   
 
 0.903
KLHL8
Kelch like family member 8.
    
 
 0.738
PDPK1
3-phosphoinositide dependent protein kinase-1.
    
0.720
PSORS1C1
Psoriasis susceptibility 1 candidate gene 1 protein homolog.
      
 0.653
CARD11
Caspase recruitment domain family, member 11.
   
 0.641
RBCK1
RANBP2-type and C3HC4-type zinc finger containing 1.
   
  
 0.579
RND1
RND1 isoform 1.
   
 0.565
RHOA
Ras homolog family member A.
   
 0.565
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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