STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM2ISM2 isoform 4. (567 aa)    
Predicted Functional Partners:
SPTLC1
Aminotran_1_2 domain-containing protein.
   
 0.887
KDSR
3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.701
SORD
Sorbitol dehydrogenase.
  
 
 0.619
ALAD
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
    
 0.619
ENSPTRP00000069545
annotation not available
  
 
 0.619
SPTSSA
Serine palmitoyltransferase small subunit A.
    
 0.614
ADHFE1
ADHFE1 isoform 2.
    
 0.579
SPTSSB
Serine palmitoyltransferase small subunit B.
    
 0.552
TGFB3
Transforming growth factor beta; Belongs to the TGF-beta family.
      
 0.551
ORMDL3
ORM1-like protein; Negative regulator of sphingolipid synthesis.
    
 
 0.528
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.