STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINA4Serpin family A member 4; Belongs to the serpin family. (427 aa)    
Predicted Functional Partners:
KLK1
KLK1 isoform 3; Belongs to the peptidase S1 family.
    
 0.904
KLK2
KLK2 isoform 5; Belongs to the peptidase S1 family.
    
 0.902
KLK4
Kallikrein related peptidase 4; Belongs to the peptidase S1 family.
    
 0.690
PI3
Peptidase inhibitor 3, skin-derived.
      
 0.672
SERPIND1
Serpin family D member 1; Belongs to the serpin family.
  
 
0.639
SERPINC1
Serpin family C member 1; Belongs to the serpin family.
  
0.608
F2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
   
 0.592
LRP6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 
 0.591
AZU1
AZU1 isoform 1.
    
 0.585
OSBP
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.540
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.