STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APBA2Amyloid beta precursor protein binding family A member 2. (751 aa)    
Predicted Functional Partners:
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
   
 0.973
APP
Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
   
 
 0.959
STXBP1
Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.
   
 0.883
CLSTN1
CLSTN1 isoform 1.
   
 
 0.860
RIMS2
Regulating synaptic membrane exocytosis 2.
   
 
 0.850
MPP1
Membrane protein, palmitoylated 1, 55kDa; Belongs to the MAGUK family.
   
 0.742
OBI1
RNF219 isoform 1.
      
 0.742
MPP1-2
Membrane palmitoylated protein 1.
   
 0.742
STXBP2
Syntaxin-binding protein 2.
   
 0.737
APLP2
Amyloid beta precursor like protein 2.
   
 
 0.707
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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