FAN1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CK820_G0052740	FAN1	ENSPTRP00000032326	ENSPTRP00000011713	PMS2 isoform 6.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.977
CK820_G0052740	MLH1	ENSPTRP00000032326	ENSPTRP00000025426	PMS2 isoform 6.	MutL homolog 1, colon cancer, nonpolyposis type 2.	0.993
CK820_G0052740	PMS1	ENSPTRP00000032326	ENSPTRP00000066616	PMS2 isoform 6.	PMS1 homolog 1, mismatch repair system component.	0.944
CK820_G0052740	PMS2	ENSPTRP00000032326	ENSPTRP00000090549	PMS2 isoform 6.	PMS1 homolog 2, mismatch repair system component.	0.900
DCLRE1A	ENSPTRP00000090750	ENSPTRP00000046846	ENSPTRP00000090750	DCLRE1A isoform 1.	annotation not available	0.764
DCLRE1A	FAN1	ENSPTRP00000046846	ENSPTRP00000011713	DCLRE1A isoform 1.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.831
DCLRE1A	FANCD2	ENSPTRP00000046846	ENSPTRP00000025203	DCLRE1A isoform 1.	FANCD2 isoform 1.	0.764
DCLRE1A	FANCI	ENSPTRP00000046846	ENSPTRP00000012702	DCLRE1A isoform 1.	FANCI isoform 2.	0.804
DCLRE1A	FANCM	ENSPTRP00000046846	ENSPTRP00000010694	DCLRE1A isoform 1.	Fanconi anemia, complementation group M.	0.820
DCLRE1A	SLX1A	ENSPTRP00000046846	ENSPTRP00000058845	DCLRE1A isoform 1.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.	0.752
ENSPTRP00000090750	DCLRE1A	ENSPTRP00000090750	ENSPTRP00000046846	annotation not available	DCLRE1A isoform 1.	0.764
ENSPTRP00000090750	FAN1	ENSPTRP00000090750	ENSPTRP00000011713	annotation not available	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.934
ENSPTRP00000090750	FANCI	ENSPTRP00000090750	ENSPTRP00000012702	annotation not available	FANCI isoform 2.	0.990
ENSPTRP00000090750	FANCM	ENSPTRP00000090750	ENSPTRP00000010694	annotation not available	Fanconi anemia, complementation group M.	0.916
ENSPTRP00000090750	MLH1	ENSPTRP00000090750	ENSPTRP00000025426	annotation not available	MutL homolog 1, colon cancer, nonpolyposis type 2.	0.666
ENSPTRP00000090750	SLX1A	ENSPTRP00000090750	ENSPTRP00000058845	annotation not available	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.	0.706
FAN1	CK820_G0052740	ENSPTRP00000011713	ENSPTRP00000032326	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	PMS2 isoform 6.	0.977
FAN1	DCLRE1A	ENSPTRP00000011713	ENSPTRP00000046846	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	DCLRE1A isoform 1.	0.831
FAN1	ENSPTRP00000090750	ENSPTRP00000011713	ENSPTRP00000090750	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	annotation not available	0.934
FAN1	FANCD2	ENSPTRP00000011713	ENSPTRP00000025203	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	FANCD2 isoform 1.	0.993