STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AVENApoptosis and caspase activation inhibitor. (358 aa)    
Predicted Functional Partners:
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
    
 0.972
BCL2L1
BCL2L1 isoform 6.
    
 
 0.750
WTIP
WT1 interacting protein.
      
 0.735
TEP1
Telomerase associated protein 1.
    
 0.708
TTC7B
Tetratricopeptide repeat domain 7B.
      
 0.702
CASP9
CASP9 isoform 4; Belongs to the peptidase C14A family.
     
 0.685
RPL39
RPL39 isoform 3.
      
 0.683
MAGED4
MAGE family member D4.
      
 0.664
PDIA3
Protein disulfide-isomerase.
      
 0.610
CST6
CST6 isoform 1; Belongs to the cystatin family.
    
 0.573
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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