STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRED1Sprouty-related, EVH1 domain containing 1. (444 aa)    
Predicted Functional Partners:
NF1
Neurofibromin 1.
    
 0.965
SPRED2
SPRED2 isoform 3.
  
  
0.900
CAV1
Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]
      
 0.787
NRAS
Neuroblastoma RAS viral (V-ras) oncogene homolog.
   
 0.776
KRAS
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.
   
 0.761
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
      
 0.712
HRAS
V-Ha-ras Harvey rat sarcoma viral oncogene homolog.
   
 0.673
RASA1
RAS p21 protein activator (GTPase activating protein) 1.
     
 0.663
LAMTOR1
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.
      
 0.655
KIT
Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.643
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.