STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VPS18VPS18 core subunit of CORVET and HOPS complexes. (973 aa)    
Predicted Functional Partners:
VPS33A
Vacuolar protein sorting 33 homolog A; Belongs to the STXBP/unc-18/SEC1 family.
   
 0.999
VPS39
VPS39 subunit of HOPS complex.
   
 0.999
VPS41
Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.
    
 0.999
VPS16
Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.
   
 0.999
VPS11
Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.
   
0.999
VPS33B
VPS33B late endosome and lysosome associated; Belongs to the STXBP/unc-18/SEC1 family.
   
 0.985
TGFBRAP1
Transforming growth factor, beta receptor associated protein 1.
   
 0.967
VPS8
VPS8 subunit of CORVET complex.
    
 0.951
VPS45
VPS45 isoform 1; Belongs to the STXBP/unc-18/SEC1 family.
    
 0.951
SGSH
N-sulfoglucosamine sulfohydrolase.
      
 0.884
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.