SHC4 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSPTRP00000069741	ENSPTRP00000069840	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.996
EGFR	ERBB3	ENSPTRP00000069741	ENSPTRP00000008639	Receptor protein-tyrosine kinase.	V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian).	0.992
EGFR	ERBB4	ENSPTRP00000069741	ENSPTRP00000063299	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.951
EGFR	GAB1	ENSPTRP00000069741	ENSPTRP00000028277	Receptor protein-tyrosine kinase.	GRB2-associated-binding protein 1.	0.996
EGFR	GRB2	ENSPTRP00000069741	ENSPTRP00000016382	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2.	0.999
EGFR	IGF1R	ENSPTRP00000069741	ENSPTRP00000012792	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.860
EGFR	INSR	ENSPTRP00000069741	ENSPTRP00000063257	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.552
EGFR	MET	ENSPTRP00000069741	ENSPTRP00000083162	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.951
EGFR	SHC3	ENSPTRP00000069741	ENSPTRP00000063600	Receptor protein-tyrosine kinase.	SHC3 isoform 2.	0.990
EGFR	SHC4	ENSPTRP00000069741	ENSPTRP00000012048	Receptor protein-tyrosine kinase.	SHC adaptor protein 4.	0.993
ERBB2	EGFR	ENSPTRP00000069840	ENSPTRP00000069741	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.996
ERBB2	ERBB3	ENSPTRP00000069840	ENSPTRP00000008639	Receptor protein-tyrosine kinase.	V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian).	0.998
ERBB2	ERBB4	ENSPTRP00000069840	ENSPTRP00000063299	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.999
ERBB2	GAB1	ENSPTRP00000069840	ENSPTRP00000028277	Receptor protein-tyrosine kinase.	GRB2-associated-binding protein 1.	0.974
ERBB2	GRB2	ENSPTRP00000069840	ENSPTRP00000016382	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2.	0.997
ERBB2	IGF1R	ENSPTRP00000069840	ENSPTRP00000012792	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.870
ERBB2	INSR	ENSPTRP00000069840	ENSPTRP00000063257	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.773
ERBB2	MET	ENSPTRP00000069840	ENSPTRP00000083162	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.814
ERBB2	SHC3	ENSPTRP00000069840	ENSPTRP00000063600	Receptor protein-tyrosine kinase.	SHC3 isoform 2.	0.984
ERBB2	SHC4	ENSPTRP00000069840	ENSPTRP00000012048	Receptor protein-tyrosine kinase.	SHC adaptor protein 4.	0.964