STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog. (666 aa)    
Predicted Functional Partners:
RTF1
Rtf1, Paf1/RNA polymerase II complex component, homolog.
   
 0.999
WDR61
WD repeat domain 61.
   
 0.999
CTR9
Ctr9, Paf1/RNA polymerase II complex component, homolog.
   
 0.999
PAF1
Paf1, RNA polymerase II associated factor, homolog.
   
 0.999
CDC73
Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog.
   
 0.999
SSRP1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
   
 0.992
CINP
Cyclin dependent kinase 2 interacting protein.
   
 0.989
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 0.988
ENSPTRP00000061528
annotation not available
   
 0.988
ELOA
Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A).
    
 0.972
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.