PML protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	DAXX	ENSPTRP00000074980	ENSPTRP00000030818	CREB binding protein.	Death domain associated protein.	0.773
CREBBP	EP300	ENSPTRP00000074980	ENSPTRP00000024841	CREB binding protein.	E1A binding protein p300.	0.999
CREBBP	PML	ENSPTRP00000074980	ENSPTRP00000012429	CREB binding protein.	PML isoform 6.	0.886
CREBBP	RARA	ENSPTRP00000074980	ENSPTRP00000053041	CREB binding protein.	RARA isoform 4.	0.726
CREBBP	RUNX1	ENSPTRP00000074980	ENSPTRP00000092866	CREB binding protein.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.856
CREBBP	SPI1	ENSPTRP00000074980	ENSPTRP00000084012	CREB binding protein.	Spi-1 proto-oncogene.	0.613
CREBBP	TP53	ENSPTRP00000074980	ENSPTRP00000014836	CREB binding protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.997
CREBBP	UBE2I	ENSPTRP00000074980	ENSPTRP00000012969	CREB binding protein.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.876
DAXX	CREBBP	ENSPTRP00000030818	ENSPTRP00000074980	Death domain associated protein.	CREB binding protein.	0.773
DAXX	EP300	ENSPTRP00000030818	ENSPTRP00000024841	Death domain associated protein.	E1A binding protein p300.	0.604
DAXX	PML	ENSPTRP00000030818	ENSPTRP00000012429	Death domain associated protein.	PML isoform 6.	0.991
DAXX	SP100	ENSPTRP00000030818	ENSPTRP00000022255	Death domain associated protein.	Nuclear autoantigen Sp-100.	0.539
DAXX	TP53	ENSPTRP00000030818	ENSPTRP00000014836	Death domain associated protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.994
DAXX	UBE2I	ENSPTRP00000030818	ENSPTRP00000012969	Death domain associated protein.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.950
EIF4E	PML	ENSPTRP00000069083	ENSPTRP00000012429	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	PML isoform 6.	0.917
EIF4E	TP53	ENSPTRP00000069083	ENSPTRP00000014836	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.460
EP300	CREBBP	ENSPTRP00000024841	ENSPTRP00000074980	E1A binding protein p300.	CREB binding protein.	0.999
EP300	DAXX	ENSPTRP00000024841	ENSPTRP00000030818	E1A binding protein p300.	Death domain associated protein.	0.604
EP300	PML	ENSPTRP00000024841	ENSPTRP00000012429	E1A binding protein p300.	PML isoform 6.	0.869
EP300	RARA	ENSPTRP00000024841	ENSPTRP00000053041	E1A binding protein p300.	RARA isoform 4.	0.796