STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CSKTyrosine-protein kinase. (450 aa)    
Predicted Functional Partners:
PAG1
Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.
    
 0.996
PTPN22
Protein tyrosine phosphatase, non-receptor type 22 (Lymphoid).
   
 0.994
SRC
Tyrosine-protein kinase.
  
0.982
PXN
PXN isoform 20.
   
 0.895
PXN-2
PXN isoform 9.
   
 0.895
PTPN12
Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.
   
 0.883
EGFR
Receptor protein-tyrosine kinase.
    
0.870
LCK
Tyrosine-protein kinase.
  
0.851
SHC1
SHC (Src homology 2 domain containing) transforming protein 1.
   
0.814
ENSPTRP00000081537
annotation not available
  
0.786
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.