STUB1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG1	BAG3	ENSPTRP00000035663	ENSPTRP00000005287	BAG1 isoform 2.	BCL2-associated athanogene 3.	0.803
BAG1	HSPA4	ENSPTRP00000035663	ENSPTRP00000029477	BAG1 isoform 2.	Heat shock protein family A (Hsp70) member 4.	0.972
BAG1	STUB1	ENSPTRP00000035663	ENSPTRP00000012898	BAG1 isoform 2.	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase.	0.943
BAG3	BAG1	ENSPTRP00000005287	ENSPTRP00000035663	BCL2-associated athanogene 3.	BAG1 isoform 2.	0.803
BAG3	HSP90AB1	ENSPTRP00000005287	ENSPTRP00000031135	BCL2-associated athanogene 3.	HSP90AB1 isoform 1.	0.434
BAG3	HSPA4	ENSPTRP00000005287	ENSPTRP00000029477	BCL2-associated athanogene 3.	Heat shock protein family A (Hsp70) member 4.	0.975
BAG3	SMAD3	ENSPTRP00000005287	ENSPTRP00000090625	BCL2-associated athanogene 3.	Mothers against decapentaplegic homolog.	0.443
BAG3	STUB1	ENSPTRP00000005287	ENSPTRP00000012898	BCL2-associated athanogene 3.	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase.	0.937
BAG3	TP53	ENSPTRP00000005287	ENSPTRP00000014836	BCL2-associated athanogene 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.533
CFTR	HSP90AA1	ENSPTRP00000033597	ENSPTRP00000070946	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.891
CFTR	HSP90AB1	ENSPTRP00000033597	ENSPTRP00000031135	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	HSP90AB1 isoform 1.	0.714
CFTR	HSPA4	ENSPTRP00000033597	ENSPTRP00000029477	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Heat shock protein family A (Hsp70) member 4.	0.850
CFTR	STUB1	ENSPTRP00000033597	ENSPTRP00000012898	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase.	0.952
EGFR	ERBB2	ENSPTRP00000069741	ENSPTRP00000069840	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.996
EGFR	HSP90AA1	ENSPTRP00000069741	ENSPTRP00000070946	Receptor protein-tyrosine kinase.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.964
EGFR	HSP90AB1	ENSPTRP00000069741	ENSPTRP00000031135	Receptor protein-tyrosine kinase.	HSP90AB1 isoform 1.	0.963
EGFR	HSPA4	ENSPTRP00000069741	ENSPTRP00000029477	Receptor protein-tyrosine kinase.	Heat shock protein family A (Hsp70) member 4.	0.935
EGFR	STUB1	ENSPTRP00000069741	ENSPTRP00000012898	Receptor protein-tyrosine kinase.	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase.	0.946
EGFR	TP53	ENSPTRP00000069741	ENSPTRP00000014836	Receptor protein-tyrosine kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.856
ERBB2	EGFR	ENSPTRP00000069840	ENSPTRP00000069741	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.996