Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa)    
Predicted Functional Partners:
ALDH5A1
Succinate-semialdehyde dehydrogenase, mitochondrial; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA); Belongs to the aldehyde dehydrogenase family.
  
 0.951
GOT1
Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]
   
 
 0.786
SEMA4B
SEMA4B isoform 1; Belongs to the semaphorin family.
      
 0.759
GAD1
Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family.
  
 0.742
SGPL1
Sphingosine-1-phosphate lyase 1.
  
 0.702
PPAT
Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
 0.672
AASDH
Aminoadipate-semialdehyde dehydrogenase.
  
 
 0.668
ALDH6A1
Aldehyde dehydrogenase 6 family, member A1.
   
  
 0.661
FH
Fumarate hydratase.
   
 0.660
ALDH7A1
ALDH7A1 isoform 8; Belongs to the aldehyde dehydrogenase family.
  
 0.641
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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