IGSF6 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IGSF6

Immunoglobulin superfamily member 6. (241 aa)

Predicted Functional Partners:

METTL9

0.792

MNDA

0.492

ITGAX

0.464

HCK

0.448

FCER1G

0.409

TYROBP

0.400

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FCER1G	HCK	ENSPTRP00000051638	ENSPTRP00000022925	Fc fragment of IgE receptor Ig.	Tyrosine-protein kinase.	0.736
FCER1G	IGSF6	ENSPTRP00000051638	ENSPTRP00000013420	Fc fragment of IgE receptor Ig.	Immunoglobulin superfamily member 6.	0.409
FCER1G	ITGAX	ENSPTRP00000051638	ENSPTRP00000078771	Fc fragment of IgE receptor Ig.	Integrin subunit alpha X; Belongs to the integrin alpha chain family.	0.577
FCER1G	MNDA	ENSPTRP00000051638	ENSPTRP00000089964	Fc fragment of IgE receptor Ig.	Myeloid cell nuclear differentiation antigen.	0.551
FCER1G	TYROBP	ENSPTRP00000051638	ENSPTRP00000018632	Fc fragment of IgE receptor Ig.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.998
HCK	FCER1G	ENSPTRP00000022925	ENSPTRP00000051638	Tyrosine-protein kinase.	Fc fragment of IgE receptor Ig.	0.736
HCK	IGSF6	ENSPTRP00000022925	ENSPTRP00000013420	Tyrosine-protein kinase.	Immunoglobulin superfamily member 6.	0.448
HCK	MNDA	ENSPTRP00000022925	ENSPTRP00000089964	Tyrosine-protein kinase.	Myeloid cell nuclear differentiation antigen.	0.862
HCK	TYROBP	ENSPTRP00000022925	ENSPTRP00000018632	Tyrosine-protein kinase.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.817
IGSF6	FCER1G	ENSPTRP00000013420	ENSPTRP00000051638	Immunoglobulin superfamily member 6.	Fc fragment of IgE receptor Ig.	0.409
IGSF6	HCK	ENSPTRP00000013420	ENSPTRP00000022925	Immunoglobulin superfamily member 6.	Tyrosine-protein kinase.	0.448
IGSF6	ITGAX	ENSPTRP00000013420	ENSPTRP00000078771	Immunoglobulin superfamily member 6.	Integrin subunit alpha X; Belongs to the integrin alpha chain family.	0.464
IGSF6	METTL9	ENSPTRP00000013420	ENSPTRP00000040796	Immunoglobulin superfamily member 6.	Methyltransferase like 9.	0.792
IGSF6	MNDA	ENSPTRP00000013420	ENSPTRP00000089964	Immunoglobulin superfamily member 6.	Myeloid cell nuclear differentiation antigen.	0.492
IGSF6	TYROBP	ENSPTRP00000013420	ENSPTRP00000018632	Immunoglobulin superfamily member 6.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.400
ITGAX	FCER1G	ENSPTRP00000078771	ENSPTRP00000051638	Integrin subunit alpha X; Belongs to the integrin alpha chain family.	Fc fragment of IgE receptor Ig.	0.577
ITGAX	IGSF6	ENSPTRP00000078771	ENSPTRP00000013420	Integrin subunit alpha X; Belongs to the integrin alpha chain family.	Immunoglobulin superfamily member 6.	0.464
ITGAX	TYROBP	ENSPTRP00000078771	ENSPTRP00000018632	Integrin subunit alpha X; Belongs to the integrin alpha chain family.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.539
METTL9	IGSF6	ENSPTRP00000040796	ENSPTRP00000013420	Methyltransferase like 9.	Immunoglobulin superfamily member 6.	0.792
MNDA	FCER1G	ENSPTRP00000089964	ENSPTRP00000051638	Myeloid cell nuclear differentiation antigen.	Fc fragment of IgE receptor Ig.	0.551