STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDR2Cerebellar degeneration-related protein 2, 62kDa. (454 aa)    
Predicted Functional Partners:
CDR2L
Cerebellar degeneration-related protein 2-like.
    
  
0.725
MYC
Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).
    
 
 0.677
SEC14L1
SEC14L1 isoform 13.
   
  
 0.654
KTN1
KTN1 isoform 4.
    
   0.628
BRSK1
BR serine/threonine kinase 1.
      
 0.587
ITIH4
Inter-alpha-trypsin inhibitor heavy chain 4.
      
 0.583
HIF3A
Hypoxia inducible factor 3 subunit alpha.
      
 0.570
WEE1
Wee1-like protein kinase.
      
 0.557
ADSS1
Adenylosuccinate synthetase isozyme 1 isoform X2.
      
 0.536
CD1D
Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells.
      
 0.520
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.