close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLK1Serine/threonine-protein kinase PLK. (621 aa)    
Predicted Functional Partners:
FZR1
Fizzy and cell division cycle 20 related 1.
   
 0.996
CDC20
Cell division cycle 20 homolog.
   
 0.994
ERCC6L
Excision repair cross-complementing rodent repair deficiency, complementation group 6-like.
   
 0.993
BUB1B
BUB1B-PAK6 isoform 4.
   
 0.993
BORA
BORA aurora kinase A activator.
   
 0.992
LOC737111
Cell division cycle protein 20 homolog pseudogene.
   
 0.992
KIF2C
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 0.988
CDC25C
CDC25C isoform 7.
   
 0.987
BUB1
BUB1 isoform 1.
   
 0.985
CDK1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
   
0.983
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.