STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)    
Predicted Functional Partners:
FGD3
FYVE, RhoGEF and PH domain containing 3.
   
  
 0.795
SMPD1
Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.
      
 0.782
ARHGEF7
Rho guanine nucleotide exchange factor 7.
      
 0.778
RUSC2
RUN and SH3 domain containing 2.
   
  
 0.762
CORO1B
Coronin; Belongs to the WD repeat coronin family.
  
 
0.754
CFL1
CFL1 isoform 2; Belongs to the actin-binding proteins ADF family.
   
 
 0.725
TYROBP
TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]
   
  
 0.723
CFL2
Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.
   
 
 0.717
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1.
      
 0.704
IFT80
Intraflagellar transport protein 80 homolog.
   
 
 0.700
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.