STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)    
Predicted Functional Partners:
CACYBP
Calcyclin binding protein.
    
 0.992
CTNNB1
Catenin (Cadherin-associated protein), beta 1, 88kDa.
    
 0.984
SNCA
Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]
    
 0.972
UBE2L6
Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.954
GAPDH
Glyceraldehyde-3-phosphate dehydrogenase.
   
 
 0.944
USP19
USP19 isoform 6.
    
 
 0.943
AXIN1
AXIN1 isoform 2.
    
 0.942
ENSPTRP00000073053
annotation not available
    
 
 0.930
LOC744191
Calcyclin-binding protein pseudogene.
    
 
 0.930
SNCAIP
SNCAIP isoform 11.
    
 0.883
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.