| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1D1 | CYP17A1 | ENSPTRP00000033814 | ENSPTRP00000069568 | Aldo-keto reductase family 1 member D1. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.912 |
| AKR1D1 | HSD11B1 | ENSPTRP00000033814 | ENSPTRP00000003270 | Aldo-keto reductase family 1 member D1. | Hydroxysteroid (11-beta) dehydrogenase 1. | 0.951 |
| AKR1D1 | HSD11B1L | ENSPTRP00000033814 | ENSPTRP00000017581 | Aldo-keto reductase family 1 member D1. | Hydroxysteroid 11-beta dehydrogenase 1 like. | 0.911 |
| AKR1D1 | HSD11B2 | ENSPTRP00000033814 | ENSPTRP00000014053 | Aldo-keto reductase family 1 member D1. | Hydroxysteroid 11-beta dehydrogenase 2. | 0.947 |
| AKR1D1 | HSD3B1 | ENSPTRP00000033814 | ENSPTRP00000002008 | Aldo-keto reductase family 1 member D1. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. | 0.919 |
| AKR1D1 | HSD3B2 | ENSPTRP00000033814 | ENSPTRP00000051923 | Aldo-keto reductase family 1 member D1. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.916 |
| AKR1D1 | LOC745345 | ENSPTRP00000033814 | ENSPTRP00000071445 | Aldo-keto reductase family 1 member D1. | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | 0.908 |
| CYP17A1 | AKR1D1 | ENSPTRP00000069568 | ENSPTRP00000033814 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aldo-keto reductase family 1 member D1. | 0.912 |
| CYP17A1 | HSD11B1 | ENSPTRP00000069568 | ENSPTRP00000003270 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid (11-beta) dehydrogenase 1. | 0.951 |
| CYP17A1 | HSD11B1L | ENSPTRP00000069568 | ENSPTRP00000017581 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid 11-beta dehydrogenase 1 like. | 0.918 |
| CYP17A1 | HSD11B2 | ENSPTRP00000069568 | ENSPTRP00000014053 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid 11-beta dehydrogenase 2. | 0.644 |
| CYP17A1 | HSD3B1 | ENSPTRP00000069568 | ENSPTRP00000002008 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. | 0.980 |
| CYP17A1 | HSD3B2 | ENSPTRP00000069568 | ENSPTRP00000051923 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.986 |
| CYP17A1 | LOC745345 | ENSPTRP00000069568 | ENSPTRP00000071445 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | 0.924 |
| HSD11B1 | AKR1D1 | ENSPTRP00000003270 | ENSPTRP00000033814 | Hydroxysteroid (11-beta) dehydrogenase 1. | Aldo-keto reductase family 1 member D1. | 0.951 |
| HSD11B1 | CYP17A1 | ENSPTRP00000003270 | ENSPTRP00000069568 | Hydroxysteroid (11-beta) dehydrogenase 1. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.951 |
| HSD11B1 | HSD11B1L | ENSPTRP00000003270 | ENSPTRP00000017581 | Hydroxysteroid (11-beta) dehydrogenase 1. | Hydroxysteroid 11-beta dehydrogenase 1 like. | 0.909 |
| HSD11B1 | HSD11B2 | ENSPTRP00000003270 | ENSPTRP00000014053 | Hydroxysteroid (11-beta) dehydrogenase 1. | Hydroxysteroid 11-beta dehydrogenase 2. | 0.994 |
| HSD11B1 | HSD3B1 | ENSPTRP00000003270 | ENSPTRP00000002008 | Hydroxysteroid (11-beta) dehydrogenase 1. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. | 0.920 |
| HSD11B1 | HSD3B2 | ENSPTRP00000003270 | ENSPTRP00000051923 | Hydroxysteroid (11-beta) dehydrogenase 1. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.924 |
