STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)    
Predicted Functional Partners:
SMPD2
Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase).
     
 0.978
SMPD1
Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.
     
 0.966
LOC459619
Uncharacterized protein.
     
 0.952
SGMS2
Sphingomyelin synthase 2.
     
 0.946
SGMS1
Sphingomyelin synthase 1.
     
 0.945
ASAH1
Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]
     
 0.937
UGCG
UDP-glucose ceramide glucosyltransferase.
     
 0.935
CERS6
Ceramide synthase 6.
     
 0.935
DEGS1
Degenerative spermatocyte homolog 1, lipid desaturase.
     
 0.928
ENPP7
Ectonucleotide pyrophosphatase/phosphodiesterase 7.
     
 0.923
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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