STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WWOXWW domain containing oxidoreductase. (414 aa)    
Predicted Functional Partners:
ERBB4
Receptor protein-tyrosine kinase.
    
 0.956
TFAP2C
Transcription factor AP-2 gamma.
    
 0.954
CK820_G0006425
TFAP2C isoform 2.
    
 0.954
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.850
FHIT
Bis(5'-adenosyl)-triphosphatase.
   
  
 0.836
DVL2
Dishevelled segment polarity protein 2.
    
 
 0.799
TFAP2A
Transcription factor AP-2 alpha.
    
 0.757
TMEM260
Chromosome 14 open reading frame 101.
      
 0.728
TCTN1
Tectonic family member 1.
      
 0.725
WBP2
WW domain-binding protein 2.
    
 
 0.722
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.