Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1C3 | CYP17A1 | ENSPTRP00000078798 | ENSPTRP00000069568 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.966 |
| AKR1C3 | CYP19A1 | ENSPTRP00000078798 | ENSPTRP00000012092 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.944 |
| AKR1C3 | CYP1A1 | ENSPTRP00000078798 | ENSPTRP00000058539 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.920 |
| AKR1C3 | HSD17B1 | ENSPTRP00000078798 | ENSPTRP00000062753 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20- alpha-HSD activity. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.957 |
| AKR1C3 | HSD17B2 | ENSPTRP00000078798 | ENSPTRP00000014332 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.968 |
| AKR1C3 | HSD17B3 | ENSPTRP00000078798 | ENSPTRP00000073561 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.966 |
| AKR1C3 | HSD17B8 | ENSPTRP00000078798 | ENSPTRP00000030804 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid (17-beta) dehydrogenase 8. | 0.918 |
| AKR1C3 | HSD3B2 | ENSPTRP00000078798 | ENSPTRP00000051923 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.962 |
| AKR1C3 | SRD5A1 | ENSPTRP00000078798 | ENSPTRP00000028677 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.956 |
| AKR1C3 | SULT1E1 | ENSPTRP00000078798 | ENSPTRP00000027719 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.922 |
| CYP17A1 | AKR1C3 | ENSPTRP00000069568 | ENSPTRP00000078798 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 0.966 |
| CYP17A1 | CYP19A1 | ENSPTRP00000069568 | ENSPTRP00000012092 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.961 |
| CYP17A1 | CYP1A1 | ENSPTRP00000069568 | ENSPTRP00000058539 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.916 |
| CYP17A1 | HSD17B1 | ENSPTRP00000069568 | ENSPTRP00000062753 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20- alpha-HSD activity. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.728 |
| CYP17A1 | HSD17B2 | ENSPTRP00000069568 | ENSPTRP00000014332 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.955 |
| CYP17A1 | HSD17B3 | ENSPTRP00000069568 | ENSPTRP00000073561 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.982 |
| CYP17A1 | HSD17B8 | ENSPTRP00000069568 | ENSPTRP00000030804 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid (17-beta) dehydrogenase 8. | 0.931 |
| CYP17A1 | HSD3B2 | ENSPTRP00000069568 | ENSPTRP00000051923 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.987 |
| CYP17A1 | SRD5A1 | ENSPTRP00000069568 | ENSPTRP00000028677 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.968 |
| CYP19A1 | AKR1C3 | ENSPTRP00000012092 | ENSPTRP00000078798 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 0.944 |
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