STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MBTPS1Membrane-bound transcription factor peptidase, site 1. (1052 aa)    
Predicted Functional Partners:
ATF6
Activating transcription factor 6.
     
 0.870
CREB3L3
cAMP responsive element binding protein 3 like 3.
   
 
 0.849
SCG5
Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro (By similarity).
   
 
 0.843
SREBF2
Sterol regulatory element binding transcription factor 2.
     
 0.818
SCAP
SCAP isoform 2.
   
 
 0.813
PCSK4
PCSK4 isoform 5; Belongs to the peptidase S8 family.
      
 0.811
SREBF1
SREBF1 isoform 6.
     
 0.802
CREB3L4
cAMP responsive element binding protein 3-like 4.
   
 
 0.787
CREB3L1
cAMP responsive element binding protein 3-like 1.
   
 
 0.787
MBTPS2
Membrane-bound transcription factor peptidase, site 2.
   
  
 0.781
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.