STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NXNNXN isoform 1. (435 aa)    
Predicted Functional Partners:
DVL1
Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...]
    
 
 0.816
TXN
Thioredoxin; Belongs to the thioredoxin family.
    
 
 0.737
NLGN1
NLGN1 isoform 1.
      
 0.712
EPB41L5
Erythrocyte membrane protein band 4.1 like 5.
      
 0.667
NRXN1
NRXN1 isoform 9.
      
 0.661
CNTNAP1
Contactin associated protein 1.
      
 0.638
LRRTM2
Leucine rich repeat transmembrane neuronal 2.
      
 0.624
NRXN2
NRXN2 isoform 2.
      
 0.592
CRB3
CRB3 isoform 3.
      
 0.576
CBLN1
Cerebellin 1 precursor.
      
 0.571
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.