STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)    
Predicted Functional Partners:
BLM
BLM isoform 1.
   
 0.999
RMI1
RMI1, RecQ mediated genome instability 1, homolog.
    
 0.999
WRN
WRN RecQ like helicase.
   
 0.999
FANCM
Fanconi anemia, complementation group M.
    
 0.998
PRIMPOL
Coiled-coil domain containing 111.
   
 
 0.998
RPA3
Replication protein A3, 14kDa.
   
 0.998
TOP3A
DNA topoisomerase III alpha.
   
 0.994
FANCA
FANCA isoform 6.
    
 0.993
CLSPN
CLSPN isoform 1.
   
 0.993
RPA2
Replication protein A2, 32kDa.
   
 0.993
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.