CXCL16 protein (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

CXCL16

Chemokine (C-X-C motif) ligand 16. (273 aa)

Predicted Functional Partners:

CXCR6

0.998

CCRL2

0.846

CCR5

0.833

CXCL10

0.809

CXCL9

0.806

CXCL6

0.801

CX3CL1

0.783

CCL5

0.771

CXCR4

0.765

CXCL1

0.757

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL5	CCR5	ENSPTRP00000083031	ENSPTRP00000025599	C-C motif chemokine.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.999
CCL5	CCRL2	ENSPTRP00000083031	ENSPTRP00000045989	C-C motif chemokine.	C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family.	0.824
CCL5	CX3CL1	ENSPTRP00000083031	ENSPTRP00000013920	C-C motif chemokine.	Chemokine (C-X3-C motif) ligand 1.	0.839
CCL5	CXCL1	ENSPTRP00000083031	ENSPTRP00000027773	C-C motif chemokine.	C-X-C motif chemokine.	0.922
CCL5	CXCL10	ENSPTRP00000083031	ENSPTRP00000027807	C-C motif chemokine.	C-X-C motif chemokine.	0.998
CCL5	CXCL16	ENSPTRP00000083031	ENSPTRP00000014690	C-C motif chemokine.	Chemokine (C-X-C motif) ligand 16.	0.771
CCL5	CXCL6	ENSPTRP00000083031	ENSPTRP00000027771	C-C motif chemokine.	C-X-C motif chemokine.	0.994
CCL5	CXCL9	ENSPTRP00000083031	ENSPTRP00000027806	C-C motif chemokine.	C-X-C motif chemokine.	0.998
CCL5	CXCR4	ENSPTRP00000083031	ENSPTRP00000074646	C-C motif chemokine.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.974
CCL5	CXCR6	ENSPTRP00000083031	ENSPTRP00000054532	C-C motif chemokine.	C-X-C chemokine receptor type 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.	0.950
CCR5	CCL5	ENSPTRP00000025599	ENSPTRP00000083031	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	C-C motif chemokine.	0.999
CCR5	CCRL2	ENSPTRP00000025599	ENSPTRP00000045989	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family.	0.617
CCR5	CX3CL1	ENSPTRP00000025599	ENSPTRP00000013920	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	Chemokine (C-X3-C motif) ligand 1.	0.958
CCR5	CXCL1	ENSPTRP00000025599	ENSPTRP00000027773	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	C-X-C motif chemokine.	0.910
CCR5	CXCL10	ENSPTRP00000025599	ENSPTRP00000027807	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	C-X-C motif chemokine.	0.981
CCR5	CXCL16	ENSPTRP00000025599	ENSPTRP00000014690	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	Chemokine (C-X-C motif) ligand 16.	0.833
CCR5	CXCL6	ENSPTRP00000025599	ENSPTRP00000027771	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	C-X-C motif chemokine.	0.824
CCR5	CXCL9	ENSPTRP00000025599	ENSPTRP00000027806	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	C-X-C motif chemokine.	0.979
CCR5	CXCR4	ENSPTRP00000025599	ENSPTRP00000074646	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.934
CCR5	CXCR6	ENSPTRP00000025599	ENSPTRP00000054532	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	C-X-C chemokine receptor type 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.	0.807