node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | BCL2 | ENSPTRP00000054216 | ENSPTRP00000090293 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BCL2 apoptosis regulator. | 0.536 |
ATM | CDKN1A | ENSPTRP00000054216 | ENSPTRP00000060292 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). | 0.651 |
ATM | CHEK2 | ENSPTRP00000054216 | ENSPTRP00000067666 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Checkpoint kinase 2. | 0.999 |
ATM | EP300 | ENSPTRP00000054216 | ENSPTRP00000024841 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | E1A binding protein p300. | 0.732 |
ATM | MDM4 | ENSPTRP00000054216 | ENSPTRP00000051283 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.879 |
ATM | TP53 | ENSPTRP00000054216 | ENSPTRP00000014836 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.998 |
ATM | TP53BP1 | ENSPTRP00000054216 | ENSPTRP00000067532 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Tumor protein p53 binding protein 1. | 0.991 |
ATM | USP7 | ENSPTRP00000054216 | ENSPTRP00000075972 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.443 |
BCL2 | ATM | ENSPTRP00000090293 | ENSPTRP00000054216 | BCL2 apoptosis regulator. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.536 |
BCL2 | CDKN1A | ENSPTRP00000090293 | ENSPTRP00000060292 | BCL2 apoptosis regulator. | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). | 0.655 |
BCL2 | CHEK2 | ENSPTRP00000090293 | ENSPTRP00000067666 | BCL2 apoptosis regulator. | Checkpoint kinase 2. | 0.457 |
BCL2 | CREBBP | ENSPTRP00000090293 | ENSPTRP00000074980 | BCL2 apoptosis regulator. | CREB binding protein. | 0.617 |
BCL2 | EP300 | ENSPTRP00000090293 | ENSPTRP00000024841 | BCL2 apoptosis regulator. | E1A binding protein p300. | 0.678 |
BCL2 | MDM4 | ENSPTRP00000090293 | ENSPTRP00000051283 | BCL2 apoptosis regulator. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.494 |
BCL2 | TP53 | ENSPTRP00000090293 | ENSPTRP00000014836 | BCL2 apoptosis regulator. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.998 |
BCL2 | TP53BP2 | ENSPTRP00000090293 | ENSPTRP00000078720 | BCL2 apoptosis regulator. | Tumor protein p53 binding protein 2. | 0.885 |
CDKN1A | ATM | ENSPTRP00000060292 | ENSPTRP00000054216 | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.651 |
CDKN1A | BCL2 | ENSPTRP00000060292 | ENSPTRP00000090293 | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). | BCL2 apoptosis regulator. | 0.655 |
CDKN1A | CHEK2 | ENSPTRP00000060292 | ENSPTRP00000067666 | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). | Checkpoint kinase 2. | 0.545 |
CDKN1A | CREBBP | ENSPTRP00000060292 | ENSPTRP00000074980 | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). | CREB binding protein. | 0.844 |