| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COMT | DRD2 | ENSPTRP00000024231 | ENSPTRP00000069610 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | 0.828 |
| COMT | DRD4 | ENSPTRP00000024231 | ENSPTRP00000005517 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. | 0.887 |
| COMT | HTR2A | ENSPTRP00000024231 | ENSPTRP00000009967 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | 5-hydroxytryptamine receptor 2A. | 0.683 |
| COMT | MAOA | ENSPTRP00000024231 | ENSPTRP00000037440 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Amine oxidase. | 0.987 |
| COMT | SLC6A4 | ENSPTRP00000024231 | ENSPTRP00000015294 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.774 |
| COMT | TPH1 | ENSPTRP00000024231 | ENSPTRP00000078167 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Tryptophan hydroxylase 1. | 0.444 |
| DRD2 | COMT | ENSPTRP00000069610 | ENSPTRP00000024231 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | 0.828 |
| DRD2 | DRD4 | ENSPTRP00000069610 | ENSPTRP00000005517 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. | 0.972 |
| DRD2 | MAOA | ENSPTRP00000069610 | ENSPTRP00000037440 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Amine oxidase. | 0.608 |
| DRD2 | SLC6A4 | ENSPTRP00000069610 | ENSPTRP00000015294 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.719 |
| DRD4 | COMT | ENSPTRP00000005517 | ENSPTRP00000024231 | DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | 0.887 |
| DRD4 | DRD2 | ENSPTRP00000005517 | ENSPTRP00000069610 | DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | 0.972 |
| DRD4 | MAOA | ENSPTRP00000005517 | ENSPTRP00000037440 | DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. | Amine oxidase. | 0.795 |
| DRD4 | SLC6A4 | ENSPTRP00000005517 | ENSPTRP00000015294 | DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.845 |
| DRD4 | TPH1 | ENSPTRP00000005517 | ENSPTRP00000078167 | DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. | Tryptophan hydroxylase 1. | 0.646 |
| DRD4 | TPH2 | ENSPTRP00000005517 | ENSPTRP00000088217 | DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. | Tryptophan hydroxylase 2. | 0.518 |
| GALM | SLC6A4 | ENSPTRP00000020344 | ENSPTRP00000015294 | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.699 |
| HTR1A | MAOA | ENSPTRP00000028964 | ENSPTRP00000037440 | 5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] | Amine oxidase. | 0.680 |
| HTR1A | SLC6A4 | ENSPTRP00000028964 | ENSPTRP00000015294 | 5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.737 |
| HTR1A | TPH1 | ENSPTRP00000028964 | ENSPTRP00000078167 | 5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] | Tryptophan hydroxylase 1. | 0.401 |
