STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERBB2Receptor protein-tyrosine kinase. (1255 aa)    
Predicted Functional Partners:
ERBB3
V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian).
  
 
0.999
SHC1
SHC (Src homology 2 domain containing) transforming protein 1.
    
 0.999
EGFR
Receptor protein-tyrosine kinase.
  
 
0.999
GRB2
Growth factor receptor-bound protein 2.
    
 0.998
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
   
 0.997
SRC
Tyrosine-protein kinase.
    
0.997
ERBB4
Receptor protein-tyrosine kinase.
  
 
0.996
ERBIN
Erbb2 interacting protein.
    
 0.996
PIK3R1
Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).
    
 0.994
NRG2
NRG2 isoform 3.
    
 0.988
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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